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This stress is similar to the types of stress cells are put under in response to exercise, meaning that it can be beneficial

We demonstrated that in senescent vascular endothelial cells, FOXO4-DRI effectively disrupts the FOXO4-p53 interaction

Smirnova et al., 2012

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In experimental autoimmune uveitis (EAU), intraocular inflammation is likewise closely associated with macrophage polarization