By decreasing the release of glucagon, a hormone that elevates blood sugar levels, semaglutide effectively dampens hunger signals in your brain
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(PubMed) ;D'Adamo E, Marcovecchio ML, Giannini C, et al
This systemic inflammation, akin to the processes described in schizophrenia, can traverse the blood-brain barrier or transmit via vagal afferents, subsequently activating microglia and exacerbating neuroinflammatory processes while impairing prefrontal cortex-mediated executive functions including decision-making and emotional regulation (270)
Tirzepatide has also been shown to increase levels of adiponectin, an adipokine involved in the regulation of both glucose and lipid metabolism, with a maximum increase of 26% from baseline after 26 weeks, at the 10 mg dosage