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Diabetic retinopathy: Rapid improvements in blood glucose control have been associated with worsening of diabetic retinopathy in some patients with pre-existing retinopathy

If your primary goal is medical weight loss rather than peptide therapy, your provider may also discuss whether GLP-1 prescription weight loss injections or Wegovy treatment may better match your health goals

Patients who or under the age of 18 or have multiple endocrine neoplasia type 2 (tumors in your glands), diabetic ketoacidosis, or a personal or family history of medullary thyroid cancer, or who have allergies to the ingredients should not use semaglutide or tirzepatide

The coordinated activation of GLP-1 receptors across these multiple sites produces the comprehensive metabolic benefits characteristic of semaglutide treatment

Brain Research, 1430 , 112125