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The biological functions of stromal cell-derived factors 1 and 1 (SDF-1 and SDF- 1, CXCL12), macrophage-derived chemokine (MDC, CCL22), interferon-inducible T cell -chemoattractant (ITAC, CXCL11), inflammatory protein-10 (IP10, CXCL10), monokine-induced by gamma interferon (MIG, CXCL9), eotaxin (CCL11), granulocyte chemotactic protein 2 (GCP2, CXCL6), and Gro (CXCL2) have been shown to be substrates for proteolytic modification by DPP4

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If palpitations are consistently occurring and significantly affecting quality of life, the appropriate response may be to pause escalation, remain at the current dose longer, or in some cases to temporarily reduce to a previously tolerated dose level

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In studies, berberine is typically taken at 500 to 1500 mg per day, divided into doses (often with meals)