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Benefits are most pronounced in older adults, vegetarians, and athletes after 4-8 weeks of consistent 1000-2000mg daily use

29 After a 6-month treatment, the mean immunostaining area for small sensory fiber increased in all fiber types, including sympathetic fibers: the epidermal, dermal and sweat gland innervation reached 92%, 80% and 69%, respectively compared with the control group

This outcome is thought to be an effect of all medications that increase GLP-1, because of both an increase in SDF-1-alpha and capillary density due to increased hypoxia-inducible factor 1-alpha and vascular endothelial growth factor

Tirzepatide reduces glucagon