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Rare Long-Term Side Effects and When to Seek Help Rare but serious long-term effects include acute kidney injury in dehydrated patients, vision changes (particularly in those with pre-existing retinopathy), and gallbladder disease secondary to rapid weight loss
21 The MAESTRO-NASH trial 2224 reported that steatohepatitis resolved without worsening of fibrosis in 25.9% of patients receiving resmetirom 80 mg and in 29.9% of those receiving 100 mg, compared with 9.7% in the placebo group, and fibrosis improved without worsening of steatohepatitis in 24.2% and 25.9%, respectively, compared with 14.2% with placebo
This suggests potential for addressing degenerative joint conditions where cartilage breakdown is the primary pathology
Spinler is professor and chair of the department of pharmacy services in the School of Pharmacy and Pharmaceutical Sciences at Binghamton University
Contribution of serotonin 3A receptor to motor function and its expression in the gastrointestinal tract
