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doi:10.1042/bj2860383
Endoplasmic reticulum stress If not quickly rectified, any of the above stresses activates the ER stress- unfolded protein response (UPR) which, in turn, exacerbates oxidative stress and elicits inflammation by activating stress response genes such as NF-kB (9, 122)
Patients with mild, recently developed deficiency typically respond more rapidly than those who have been deficient for months or years
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