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doi: 10.3389/fcell.2023.1138504, 88
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Lancet Diabetes Endocrinol 4(11):913921
Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints
Another study also indicated that exendin-4 improved memory impairment by dampening the AMPK/NF-B pathway, reducing levels of IL-1 and TNF-, and increasing synaptic protein levels (118)
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