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This route may still be effective when the intended mechanism is systemic immunomodulation or release of circulating paracrine factors [36,37,38,39, 42,43,44]

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After exclusions, the final cohort comprised 69,047 short-term users and 133,387 long-term users

The urinary effects of dose escalation are typically milder and shorter-lived than the initial adjustment, but they can catch people off guard if they thought the bathroom trips were behind them