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All housing, handling, and experimentation that involved the rats were conducted following the procedures set in place by the National Institutes of Health guide for the care and usage of laboratory animals [2]
Semaglutide is already listed on the Ontario drug formulary a list of publicly covered medications for those over age 65, people living in long-term care homes, and for people receiving Ontario Works or disability payments
Epigenetic alterations, including decreased DNA methylation and modified histone marks (H3K9, H4K12), further compromise oocyte quality and meiotic progression [99]
doi: 10.1016/j.bbadis.2016.04.017 54
