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Over one year, liraglutide did not significantly improve the primary endpoint (change in cerebral glucose metabolic rate in certain brain regions), but secondary endpointsincluding brain volume loss, and cognitive measuresshowed benefit: ~50% less loss in several brain regions compared to placebo

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This article reviews the trial history

A compound capable of delivering profound weight loss while supporting glycemic control and possibly sparing muscle a rare combination in obesity pharmacology