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From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models
However, the main difference lies in the velocity at which the disease progresses towards its fatal outcome: the acute phase is reached over weeks to months or over years whether the host is infected by the rhodesiense or the gambiense strain (Lindner et al., 2025)
It undergoes significant first-pass metabolism in the liver and intestines, where the enzyme arginase breaks it down, reducing bioavailability
Every milliliter of solution contains 2.5 mg of peptide