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[National Museum of Natural History
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Despite robust clinical evidence, barriers such as high costs, limited access, lack of awareness of approved indications, and practitioner hesitancy continue to impede widespread adoption
The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)
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