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MOTS-c is involved in metabolic regulation at the cellular and organismal levels through autocrine and paracrine secretions (Miller et al., 2020)

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The tissue-specific effect of l-carnitine was found in many experiments in mammals or fish, in which the carnitine content of muscle was relatively stable, whereas the liver was more sensitive to carnitine supplementation or deficiency ( Reference Li, Li and Qin 32 , Reference Morand, Bouitbir and Felser 48 , Reference Wchter, Vogt and Kreis 49 )

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This is because, like many antidepressants, supplementary 5-HTP raises the amount of serotonin in the brain, so the combination could result in dangerous levels of the neurotransmitter.8 39 With that being said, lets take a look at how 5-HTPs ability to boost serotonin could be beneficial for those dealing with PMDD

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