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For people with obesity-related conditions like type 2 diabetes, cardiovascular disease, or sleep apnea, that delay carries medical risk
This effect is thought to involve GLP-1 and a related hormone, peptide YY (PYY)
This concern can be managed through proper medication timing, as levothyroxine should be taken on an empty stomach, typically 30-60 minutes before breakfast, while GLP-1 medications are administered at different times depending on the specific formulation
Most side effects, especially digestive symptoms, are strongest during the first few weeks or after dose increases
The interconversion between these two forms is facilitated by an enzyme called glutathione reductase, which is accompanied by the provision of NADPH via its coenzyme
