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These types of reactions often look like small red spots or a mild heat-like rash and usually subside as the body finds its new balance
The lid domain and glycine-rich loop are critical for ATP binding, which triggers major shifts in their conformations (Galant et al., In the structures of human and yeast GS, two alanine residues form van der Waals contacts with the glycine moiety of glutathione (Polekhina et al., These structure/function studies established the basis of glutathione versus homoglutathione specificity, but it remains unclear how other glutathione analogs are formed in different plants
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