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Phentermine-topiramate (Qsymia) combines phentermine with an anti-seizure medication to promote weight loss and is on average the most effective oral medication, says Johnson-Rabbett
A separate study demonstrated dose-dependent increases in longitudinal bone growth from 42 microns/day in controls to 52 microns/day at the highest dose (450 mcg/day)
However, Ozempic quickly gained attention for its weight loss benefits, leading to widespread off-label use by weight loss patients
The gradual approach allows the body to adjust safely while improving the effectiveness of appetite control
Kraemer W, Volek J, Spiering B, et al
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