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This oxidative stress is linked to various chronic diseases, including heart disease, cancer, and neurodegenerative conditions
R Clinical implications of slow acetylation: Increased risk of isoniazid-induced hepatotoxicity and peripheral neuropathy (tuberculosis treatment) R Increased risk of sulfonamide hypersensitivity reactions R Increased risk of aromatic amine-related bladder cancer in occupational exposure settings (dye workers, rubber industry) R Drug-induced lupus from hydralazine and procainamide occurs almost exclusively in slow acetylators R Altered caffeine metabolism (slow acetylators clear caffeine more slowly via the NAT2 pathway) R NAT1 polymorphisms are less well characterized but the slow allele NAT1*14 has been associated with increased risk of cancers from dietary aromatic amines
This supports broader research into how compounds interact with interconnected biological systems
Recent investments in building and expanding manufacturing capacity have helped grow supply, Novo said
Epub 2007/02/21 Fenkci SM, Fenkci V, Oztekin O, Rota S, Karagenc N
