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Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimers disease

It was demonstrated, that metabolic disturbances in hypothalamic astrocytes, caused either by selective knock-out of insulin receptors or decreased generation of reactive oxygen species (ROS) modulated glucose transport via BBB and also led to modification in behavioral responses in experimental animals [95, 96]

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Controlled studies have reported finding: Associated with changes in visceral adipose tissue markers in specific clinical research populations Lipid metabolic pathways modulation