surmount 5 tirzepatide SURMOUNT-5: (Zepbound) Proves Benefit over Semaglutide (Wegovy) for Obesity GLP-1.Reviews on X: "The SURMOUNT-5

COGNITIVE FUNCTION AND NEUROPROTECTION Neurogenic Effects of GH/IGF-1: Hippocampal neurogenesis: increase in new cells 40% Synaptic plasticity: Long-term potentiation (LTP) BDNF: Upregulation of 60% in the hippocampus/cortex Myelination: oligodendrocyte support, white matter integrity Cognitive Function: Spatial Memory: Morris Water Maze 30% Improvement Working memory: enhanced T-maze performance Processing speed: reduced response times 15% Neuroprotection: Reduction of neuronal death in ischemia models 45% Neurodegenerative Models Alzheimer's: 30% -amyloid reduction, improved cognition Parkinson's Disease: Protection of Dopaminergic Neurons 40% Aging: Partial Reversal of Age-Related Cognitive Decline 4

Safety analyses included data from all enrolled patients, and PK and PD analyses included data from all patients who received at least one dose of study treatment and for whom evaluable data were available

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Side effects typically improve after the first few weeks at each new dose

This multifaceted approach is particularly significant for many of us in Covington who may face these health challenges