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The drug remains in active clinical development, with Phase 3 trials currently underway evaluating retatrutide's efficacy and safety across broader populations, including individuals with obesity, type 2 diabetes, and cardiovascular disease
hpCAFs derived from dysmetabolic PDAC chemotherapy nave patients showed higher levels of P4HA1, collagens, hydroxyproline and collagen contraction ability To get insight into P4HA1 stromal role upon metabolic syndrome, a biobank of hpCAFs, established from 30 PDAC chemotherapy nave patients undergoing pancreatic eco-endoscopy, was exploited (Suppl
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