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11 Conclusion and future perspectives Several studies have indicated that an imbalance between oxidative stress and antioxidant defense mechanisms is linked to the onset of ND and MD

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Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues

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Vitamin C When kidney function is impaired, the body does not properly balance vitamins and mineralsespecially water-soluble vitamins like vitamin C, says Retelny