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Waist circumference was measured at the midpoint between the lower margin of the last palpable rib and the top of the iliac crest
The final concentration of 25 M FOXO4-DRI was added to the cells in a DMEM containing 2% FBS or 10% FBS
Recent studies have demonstrated the feasibility of synthesizing a novel metal-polyphenol-based multifunctional nanomedicine (Fe-dbef) containing various inhibitors, such as EGCG and BPTES, among others
Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)
33 , e13871 (2020)
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