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the prototype MT-II itself has remained without an active clinical development sponsor since 2000
Changes in HbA1c throughout the study were also not associated with reduced MACE.24 Additionally, the multiple pleiotropic effects of SEMA on metabolic, hepatic and renal function may indirectly contribute to cardiovascular protection.25 The HFpEF programme shows significant symptomatic improvement of heart failure symptoms with preserved ejection fraction (HFpEF) in obese patients treated with SEMA 2.4 mg26 (Fig
Obesity represents not merely excessive adiposity but a pathophysiological state that triggers multiple metabolic disturbances, including insulin resistance, dysregulated lipid metabolism, and oxidative stress 27,28
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