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Chinda et al (22) reported that the administration of vildagliptin (another DPP-4 inhibitor) prior to LAD occlusion in a rat ischemia/reperfusion model, modulated cardiac electrophysiology by normalizing the shortening of the effective refractory period, decreasing the occurrence of premature ventricular contractions and increasing the ventricular fibrillation threshold during the ischemic period
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The evidence is promising, but it is preclinical
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