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Due to (temporarily) reduced sodium reuptake while continuously promoting glucosuria, these drugs induce a reduction in GFR likely via activation of tubuloglomerular feedback (TGF) that may represent reduced intraglomerular pressure [5]

Prebiotics: Non-digestible fibres that promote the growth of beneficial bacteria in the gut, such as Bifidobacteria and Lactobacillus, helping to improve digestion and nutrient absorption

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However, discontinuing the drugs can often lead to rebound weight gain or the worsening of metabolic health