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a , In silico docking of GSH to GPX4 U46C , GPX4 K48A , or GPX4 K48L
Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability
(2020) 13(1):dmm042655 doi: 10.1242/dmm.042655
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