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Ruelland, E., Vaultier, M.-N., Zachowski, A
The binding modes of the clinically most widely used DPP-4 inhibitors have been characterized and based on these findings, three different classes of DPP-4 inhibitors have been proposed: Class 1 comprises of saxagliptin and vildagliptin, interacting with the S1- and S2 subsites of the active center and covalently binding with Ser630 of the DPP-4 molecule
In another study, (Val 8 )GLP-1 might prevent age-related neurodegenerative changes (such as AD) by preventing decline of learning and memory formation, reduction of tau hyperphosphorylation and protection of subcellular structures and morphology of neurons (149)
Retrieved from Centers for Disease Control and Prevention
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