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It is well documented that patients with neurofibromatosis type 1 (NF1) have a greater lifetime risk of developing MPNSTs (813%) and worse prognosis in comparison with sporadic cases, with 5-year disease-specific survival of 1638% versus 4257%, respectively [2, 5,6,7,8,9,10]
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Hydration supports absorption and reduces side effects
Development of potent H 2 O 2 -decomposing enhancers for Hb pseudoperoxidase activity Although HTPEB enhances the peroxidase-like activity of Hb, its poor BBB permeability and solubility in aqueous solutions limit its therapeutic potential (Supplementary Table 1)
We present some clinical trials of IR intervention in Table 2
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