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The peptide needs to be administered as close to the affected level as practically possible for maximum effect
Peer-reviewed preclinical data synthesis
The review documented GLP-1s rapid inactivation by DPP-4 even before the hormone has left the gut raising the hypothesis that GLP-1s actions may be partially transmitted via sensory neurons in the intestine and liver expressing the GLP-1 receptor rather than solely through systemic endocrine circulation
This is because the drug causes thyroid C-cell tumors in rodents (the incidence has not been determined in humans)
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