49% in placebo), sex was included as a covariate in all ANCOVA models
More specifically, GLP-1R expression has been identified in several hypothalamic and basal forebrain regions, including the paraventricular nucleus, supraoptic nucleus, infundibular nucleus/arcuate nucleus, lateral hypothalamic area, and nuclei of the basal forebrain, where they exhibit relatively well-defined regional expression patterns (43, 44)
The concern isnt just that youll develop antibodies against the peptide itselfits that those antibodies might cross-react with your own endogenous proteins
In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (5, 117, 118)
Things that wouldve been totally fine before