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Archived from the original (PDF) on 5 October 2011

The protective effect occurred even when the animals continued eating a high-fat diet

On the other hand, the GIP receptor impact complements this, boosting insulin response post-meals while dampening appetite

Schwalfenberg GK, Genuis SJ

The STEP 1 trial, published in the New England Journal of Medicine, showed that this sustained caloric reduction led to an average weight loss of 14.9% of body weight over 68 weeks