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In total, seven studies assessed different oral doses of semaglutide.1521 Additionally, 4 and 9 studies analysed low (0.51mg) and high (1.72.4mg) weekly subcutaneous doses of semaglutide, respectively.6,2334 One study evaluated two active arms: daily oral semaglutide and weekly subcutaneous semaglutide at doses of 0.51mg.22 Overall, 12 studies included all patients with T2DM,1520,22,2426 while another 7 studies considered this condition as an exclusion criterion (instead studying patients with overweight or obesity).6,21,2731 Two studies included patients with or without T2DM.32,34 Across all studies, a history of pancreatitis was consistently regarded as an exclusion criterion

cDNAs of tissues total RNA were synthesized using a PrimerScript TM RT reagent Kit with a gDNA Eraser (Perfect Real Time)(Takara, Japan) by S1000 TM Thermal Cycler (Bio-Rad, USA)

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The lipid phase consisted of carbohydrates and hydrogenated phosphatidylcholine combined in a 9:1 molar ratio