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Nanoemulsions (NEs) boost oral BBR bioavailability by 212% via CYP2D6 and 3A4 metabolic shielding in HFD-fed rats [209]
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This likely reflects methodological characteristics inherent to in vitro research, where randomization and blinding are usually not applicable, rather than a true source of systematic bias
By directly activating hepatic glucose production pathways between meals, promoting lipolysis, and increasing thermogenesis, the glucagon component adds a fundamentally different mechanism of action to the research equation
For example, a randomized, double-blind, placebo-controlled trial in patients with overweight or obesity -associated KOA assessed the effects of liraglutide (3 mg/day) over 52 weeks as an add-on to dietary guidance [47, 48]
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