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Furthermore, the fact that tracer retention in cortical regions increased with clinical disease severity, as estimated by the Revised ALS Functioning Rating Scale (ALSFRS-R), suggested that OS may be an important factor associated with the development of neurodegeneration in ALS patients [107]

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Avoid leaving the vial at room temperature for more than a few hours

Surprisingly, the expected intramolecular disulfide between the two cysteines of the CPYC motif was barely formed in the presence of dithiane (Supplementary Fig