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This pattern may suggest an allergic response or other complication requiring evaluation

SAMe has been shown to provide a benefit in a variety of liver disorders (modeled in experimental animals, in humans, and in dogs and cats), the molecular basis of SAMe's protective effects have been demonstrated in vitro using hepatocyte cell cultures

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Other side effects may include dizziness, headaches, increased heart rate, infections, and dyspepsia

The rationale is that glucagon-receptor agonism increases energy expenditure and promotes hepatic lipid mobilization, effectively adding a burn component on top of the eat less component supplied by GLP-1