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This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]

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AOD-9604 may address exactly that problem

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Enzyme activities also exhibited moderate to strong correlations with TPC and TFC: SOD (r=0.989 and 0.890), CAT (r=0.891 and 0.975), PPO (r=0.893 and 0.871), and GPX (r=0.718 and 0.743) (Supplementary Fig