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Three DNA methyltransferase enzymes catalyze DNA methylation: Dnmt1, Dnmt3a, and Dnmt3b, which catalyze the transfer of a methyl group of S-adenosylmethionine (SAM) to the fifth carbon position of cytosine 26
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The inhibition of PLA2G2A by an siRNA or the pharmacological action of tanshinone I led to decreased FASN expression, which was accompanied by reduced lipid synthesis and impaired mitochondrial oxidative phosphorylation, providing a potential targeted therapeutic strategy for eliminating Kras-driven pancreatic cancer cells [217]
127 , 962S965S (1997)
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