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STEP 5: In adults with obesity or overweight with at least one weight-related comorbidity, along with diet and exercise, Significant weight loss that lasts with Wegovy 2.4 mg 3 Co-primary end point: Mean change in body weight (%) from week 0 to week 104 3 During the trial, 13% of patients in the Wegovy arm discontinued treatment compared with 27% in the placebo arm
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Mazdutide is another GLP-1/glucagon dual agonist with a different potency balance and separate trial program, while retatrutide is a triple agonist that adds GIP-receptor activity
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