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Its biological meaning depends heavily on context, including the tissue being studied, the local oxidative environment, the NOS isoform involved, and the timing of measurement after experimental injury or stimulation
In clinical trials, most patients saw significant improvement in acne by week 12, but best results were measured at week 16.2 Those who follow a regular, prescribed skin care regimen can expect to see the best results, soonest
However, if serum cobalamin concentration is within the normal range, treatment should be continued at least monthly and the owner should be forewarned that clinical signs may recur sometime in the future
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