Pre-existing renal impairment is a critical factor in prescribing decisions
Individual Variability in Dose Response: Why 5 mg Isn't Universal Two patients at the same 5 mg dose may experience markedly different responses due to differences in metabolism, gastrointestinal physiology, baseline metabolic rate, and medication interactions
If additional glycaemic control is needed after at least 30 days on 7 mg, the dose may be increased to 14 mg once daily
The tool consists of seven domains, including random sequence generation, allocation concealment, performance bias, reporting bias, detection bias, attrition bias and other sources of bias
23 As shown in TABLE 2 , recommended nonpharmacologic interventions to reduce GI AEs include dietary modifications such as eating smaller, more frequent meals