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A well-characterized example is ezatiostat (TLK199)a GSH peptidomimetic moleculedesigned to display enhanced cellular uptake and whose metabolites bind the G-site of GSTP1-1 causing enzyme inhibition
The mean age of patients was 39.9 years and most (71%) were women
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Across the program, tirzepatide demonstrated dose-dependent HbA1c reductions of 1.9% to 2.6% from baseline, with many participants achieving HbA1c targets below 7.0% and even below 5.7%
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