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We generally prioritize the most challenging specificity or activity changes early in the evolutionary process when the wild-type enzyme has the highest folding energy reserves to accommodate the impact of mutations that arise during evolution 36
In addition, Wang et al., using organic proteomics and metabolomics approaches, identified a new mitochondrial transporter, SLC25A39, and highlighted its essential role in proliferation
Chang et al, 2017
Berkeley News Archive
Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation
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