DOI: 10.2147/CCID.S128339
Regulatory framework and challenges for live biotherapeutic products in Taiwan
Friml J, Vieten A, Sauer M, Weijers D, Schwarz H, Hamann T et al (2003) Efflux-dependent auxin gradients establish the apicalbasal axis of Arabidopsis
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
The most well characterized classes have been named alpha (GSTA), mu (GSTM), pi (GSTP) and theta (GSTT)