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Studies show the most common side effects of oral glutathione supplements are: Flatulence or gas Loose stools Bloating Abdominal cramping (typically mild) The good news is that these side effects are typically mild and usually occur when youve just started the supplement or because youre taking too high a dose

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The mechanism is well-characterized at the biochemical level: GSH inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis, by binding to its copper-containing active site

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Billington et al, 2013)