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10.1186/cc9098 77 GalleyH
The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]
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DSIP appears to affect sleep depth and quality rather than timing
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