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It should be noted that hyperuricemia in both men and women is a significant contributor to the development of non-alcoholic fatty liver disease (NAFLD), diabetes, the metabolic syndrome, and obesity
Like other enzymes that transfer two-carbon groups, transketolase requires thiamine pyrophosphate (TPP) as a co-factor in the transfer reaction
Both are biologically plausible, and both have limited supportive human evidence
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