Philadelphia: W
Today, glutathione remains a cornerstone of biomedical research and continues to be investigated for its involvement in aging, metabolic health, immune function, neurological health, and cellular resilience
Studies have shown that glutathione supplementation can help enhance cognitive function, support mental clarity, and reduce the risk of neurodegenerative conditions such as Alzheimers and Parkinsons disease
Ethics declarations Ethics approval statement and consent to participate All mouse procedures were approved by the Health Sciences Animal Ethics Committee of The University of Queensland (2021AE000537 and 2021AE000155) and by the US Department of Defense Animal Care and Use Review Office (approval SC00080.e001), and performed in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes
Glutamate, cysteine, and glycine are precursors for GSH, and GPX4 inactivation can induce ferroptosis via GSH/GPX4[29]