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A double-blind, placebo-controlled trial by Chez et al
Vehicle controls in matched buffer, GHRP-6 or GHRP-2 as non-selective GHS reference compounds at equivalent molar concentrations, GHS-R1a antagonist [D-Lys3]-GHRP-6 confirming receptor specificity, and concurrent prolactin and cortisol measurement endpoints confirming selectivity in the specific model and species used
the Daly 2025 APOE4-homozygote prevention case
The combination is biochemically logical, but there is not yet a strong human trial proving that NMN + TMG yields better longevity outcomes than NMN alone
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