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Some researchers found that the expression of phosphofurin acidic cluster sorting protein 2 (PACS-2), a key regulator of MAM formation, was significantly reduced in renal tubules of DN patients, and PACS-2 was found to attenuate renal tubular injury through advancing MAM formation and mitophagy in a cellular model of HG-induced HK-2 and PACS-2 overexpression, and in a mouse model of STZ-induced PACS-2 knockout [121]

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DOI: Published online: April 1, 2024 Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China Corresponding authors: Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China E-mail: [email protected] Xia Deng Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China E-mail: [email protected] Copyright 2024 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

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